SX-682, CXCR1/2 inhibitor (TBI4925)
$198.00 – $765.00
CXCR1/2 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4925-5MG | Yes | 5 MG | $198.00 | |||
TBI4925-25MG | Yes | 25 MG | $765.00 |
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Description
Product Details
Formal Name: [2-[[5-[(4-Fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid
Molecular Formula: C19H14BF4N3O4S
Formula Weight: 467.20
CAS Number: 1648843-04-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
CXCR1/2 inhibitor
Functions
SX-682 is a novel CXCR1/2 inhibitor (IC50s: CXCR1 = 42 nM, CXCR2 = 20 nM). It displayed robust synergistic activity with immune checkpoint blockade against castration resistant prostate cancer. It significantly reduced tumor burden in a Ptenfl/fl/Lkb1fl/fl mouse model of lung squamous cell cancer when used in combination with anti-PD1 therapy. SX-682 significantly inhibited trafficking of neutrophilic myeloid-derived suppressor cells (PMN-MDSCs) enhancing anti-PD1 immune checkpoint blockade, T cell-based immunotherapy, and NK-cell immunotherapy.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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