BML-277, CHK2 inhibitor (TBI1024)
$108.00 – $378.00
CHK2 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1024-5MG | Yes | 5 MG | $108.00 | |||
TBI1024-25MG | Yes | 25 MG | $378.00 |
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Description
Product Details
Formal Name: 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
Molecular Formula: C20H14ClN3O2
Formula Weight: 363.81
CAS Number: 516480-79-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
CHK2 inhibitor
Functions
Potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows less that 25% inhibition of any other kinase at 10 µM, demonstrating the selectivity. Also displays radioprotective activity, preventing apoptosis in human T-cells that were subjected to ionizing radiation (EC50 = 3.0 – 7.6 µM).
Application Procedures
First dissolved in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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