NVP-231, Ceramide kinase inhibitor (TBI4694)
$72.00 – $234.00
Ceramide kinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4694-5MG | Yes | 5 MG | $72.00 | |||
TBI4694-25MG | Yes | 25 MG | $234.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide
Molecular Formula: C25H25N3O2S
Formula Weight: 432.00
CAS Number: 362003-83-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Ceramide kinase inhibitor
Functions
NVP-213 is a reversible inhibitor of ceramide kinase (IC50 = 12 nM). At 10 nM, it inhibited ceramide-1-phosphate formation by >50% and at 100 nM it completely inhibited its formation in cell culture. NVP-231 was inactive against hSphK1/2, hPI3Ka, hPI4Kb, hVps34, hGCS, hSMS-1, CERT, and 500-fold less potent against hDAGKa. NVP-231 inhibited breast and lung cancer cell proliferation via M phase arrest. It potently blocked cell migration and invasion in PANC-1 pancreatic cancer cells as well as MDA-MB-231 breast cancer cells.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “NVP-231, Ceramide kinase inhibitor (TBI4694)”
You must be logged in to post a review.
Reviews
There are no reviews yet.