STO-609, CAMKK inhibitor (TBI1036)
$135.00 – $522.00
CAMKK inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1036-5MG | Yes | 5 MG | $135.00 | |||
TBI1036-25MG | Yes | 25 MG | $522.00 |
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Description
Product Details
Formal Name: 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate
Molecular Formula: C19H10N2O3 ∙ CH3COOH
Formula Weight: 314.30 ∙ 60.05
CAS Number: 52029-86-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 10 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
CAMKK inhibitor
Functions
Selective inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki = 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively). Binds to the ATP-binding site. Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK. Important tool for probing distinct CaMK pathways in LTP. Reduces starvation-induced autophagosomal membrane formation. Reverses age-associated decline in bone mass. Stimulates osteoblast formation, inhibits osteoclast differentiation.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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