PD-150606, Calpain inhibitor (TBI1515)
$124.00 – $497.00
Calpain inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1515-5MG | Yes | 5 MG | $124.00 | |||
TBI1515-25MG | Yes | 25 MG | $497.00 |
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Description
Product Details
Formal Name: (Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid
Molecular Formula: C9H7IO2S
Formula Weight: 306.12
CAS Number: 179528-45-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Calpain inhibitor
Functions
A selective, cell-permeable non-peptide calpain inhibitor (Ki for μ- and m-calpains = 0.21 and 0.37 μM respectively). Acts at the calcium binding site of calpain rather than the substrate-binding site. Inhibits calpain activity in two intact cell systems. Attenuates hypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices. Displays cytoprotective effects in oxidant- and calcium ionophore-induced cell death. Some protective effects may be due to inhibition of MMP activity.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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