LFM-A13, BTK inhibitor (TBI1032)
$99.00 – $396.00
BTK inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1032-5MG | Yes | 5 MG | $99.00 | |||
TBI1032-25MG | Yes | 25 MG | $396.00 |
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Description
Product Details
Formal Name: (2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide
Molecular Formula: C11H8Br2N2O2
Formula Weight: 360.00
CAS Number: 62004-35-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 15 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
BTK inhibitor
Functions
LFM-A13 is a selective inhibitor of Bruton’s tyrosine kinase (BTK) – IC50’s = 2.5 µM (recombinant BTK) and 17.2 µM (human BTK). It has also been shown to inhibit Polo-ilke kinase (PLK) – IC50 = 61 µM for human PLK3. It displayed no activity (concentrations up to 278 µM) at JAK1, JAK3, HCK, EGFRK and IRK2 or CDK1-3, CHK1, IKK, MAPK1, SAPK2a and ten tyrosine kinases.
Application Procedures
First dissolved in DMSO (up to 15 mg/ml) or in Ethanol (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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