Dabrafenib (GSK2118436), B-Raf mutant inhibitor (TBI1569)
$72.00 – $306.00
B-Raf mutant inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1569-5MG | Yes | 5 MG | $72.00 | |||
TBI1569-25MG | Yes | 25 MG | $306.00 |
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Description
Product Details
Formal Name: N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide
Alternate Names: GSK2118436
Molecular Formula: C23H20F3N5O2S
Formula Weight: 519.56
CAS Number: 1195765-45-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 1 mg/ml with warming).
Storage: -20°C
Stability: ≥ 1 year.
Applications
B-Raf mutant inhibitor
Functions
Dabrafenib is a selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50 = 3.2 and 5 nM, respectively). Has been in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors. Endoplasmic reticulum stress and autophagy are induced in melanoma cells after treatment with dabrafenib and protect cells from dabrafenib toxicity. Induces epithelial differentiation in BRAF-mutant colorectal cancer cells.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), or in Ethanol (up to 1 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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