PLX-4032, B-Raf inhibitor (TBI2928)
$72.00 – $261.00
B-Raf inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI2928-5MG | Yes | 5 MG | $72.00 | |||
TBI2928-25MG | Yes | 25 MG | $261.00 |
$72.00 – $261.00
B-Raf inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI2928-5MG | Yes | 5 MG | $72.00 | |||
TBI2928-25MG | Yes | 25 MG | $261.00 |
Formal Name: N-[3-[[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Alternate Names: Vemurafenib; R7204; Ro 51-85426
Molecular Formula: C23H18ClF2N3O3S
Formula Weight: 489.92
CAS Number: 918504-65-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 100 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
B-Raf inhibitor
An ATP-competitive inhibitor of mutant V600E/F and wild type B-Raf, IC50s=31 and 100 nM respectively. Induced growth inhibition, G0/G1 arrest and apoptosis in a variety of cancer cell lines, with a B-Raf mutation favoring but not guaranteeing a response. Inhibits the growth of B-Raf V600E-positive melanomas in vitro and in vivo. Treatment of patients that carry the V600E BRAF mutation resulted in complete or partial tumor regression.
First dissolved in DMSO (up to 100 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
SIZE (mg) | 25 MG, 5 MG |
---|
You must be logged in to post a review.
Reviews
There are no reviews yet.