ABT-263, Bcl-2 family inhibitor, Senolytic agent (TBI3141)
$108.00 – $360.00
Bcl-2 family inhibitor, Senolytic agent
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI3141-5MG | Yes | 5 MG | $108.00 | |||
TBI3141-25MG | Yes | 25 MG | $360.00 |
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Description
Product Details
Formal Name: 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)- 3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]-phenyl]sulfonyl]-benzamide
Alternate Names: Navitoclax
Molecular Formula: C47H55ClF3N5O6S3
Formula Weight: 974.6
CAS Number: 923564-51-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Bcl-2 family inhibitor, Senolytic agent
Functions
Potent and selective Bcl-2 family inhibitor / BH3 domain mimetic which binds to Bcl-2, Bcl-xL and Bcl-w (Ki<1 nM). A useful tool compound which has shown interesting results in various cancer clinical trials. Synergizes with deoxyglucose and other agents, inducing apoptosis in cancer cells in a xenograft mouse model. A novel senolytic agent, inducing apoptosis preferentially in senescent cells in a cell type-restricted manner.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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