Obatoclax (GX15-070), Bcl-2 antagonist. Induces apoptosis (TBI2660)
$126.00 – $497.00
Bcl-2 antagonist. Induces apoptosis
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI2660-5MG | Yes | 5 MG | $126.00 | |||
TBI2660-25MG | Yes | 25 MG | $497.00 |
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Description
Product Details
Formal Name: 2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate
Alternate Names: GX15-070
Molecular Formula: C20H19N3O · CH3SO3H
Formula Weight: 413.50
CAS Number: 803712-79-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 5 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Bcl-2 antagonist. Induces apoptosis
Functions
A novel Bcl-2 homology domain-3 (BH3) mimetic. Inhibits primary acute myeloid leukemia (AML) progenitor cell proliferation (IC50=0.18 μM) and induces apoptosis in primary AML cells (IC50= 3.6 μM). Synergizes with other agents such as chloroquine and cytarabine in cytotoxicity against a variety of cancer cells.
Application Procedures
First dissolved in DMSO (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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