iJMJD6, Arginine demethylase JMJD6 inhibitor (TBI4039)
$135.00 – $513.00
Arginine demethylase JMJD6 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4039-5MG | Yes | 5 MG | $135.00 | |||
TBI4039-25MG | Yes | 25 MG | $513.00 |
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Description
Product Details
Formal Name: 3-(3H-Imidazo[4,5-c]pyridine-2-yl)-6-methylchromen-2-one
Alternate Names: WL12
Molecular Formula: C16H11N3O2
Formula Weight: 277.30
CAS Number: 899548-78-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 12 mg/ml with warming)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Arginine demethylase JMJD6 inhibitor
Functions
Inhibitor of the arginine demethylase JMJD6 (IC50 = 220 nM) with selectivity over other JmjC domain-containing proteins. Exhibited antiproliferative effects in HeLa (EC50 = 1.49 µM), SMCC7721 (EC50 = 9.37 µM), and MCF7 (EC50 = 9.53 µM) cells. Displayed no cytotoxicity towards normal cervical, liver, and breast epithelial cells. iJMJD6 significantly suppressed tumor growth in a HeLa, SMCC7721, MCF7, MDA-MB-231, U87, and HCT116 mouse xenograft models.
Application Procedures
First dissolved in DMSO (up to 12 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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