Dubermatinib, AXL inhibitor (TBI4679)
$108.00 – $405.00
AXL inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4679-5MG | Yes | 5 MG | $108.00 | |||
TBI4679-25MG | Yes | 25 MG | $405.00 |
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Description
Product Details
Formal Name: 2-[[5-Chloro-2-[4-[(4-methylpiperazine-1-yl)methyl]pyrimidine-4-yl]amino]-N,N-dimethylbenzenesulfonamide
Alternate Names: TP-0903
Molecular Formula: C24H30ClN7O2S
Formula Weight: 516.10
CAS Number: 1341200-45-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
AXL inhibitor
Functions
Potent (IC50 = 27 nM) inhibitor of the TAM family kinase AXL. It displayed potent activity against the pancreatic tumor cell line PSN-1 (IC50 = 6 nM). Dubermatinib also strongly inhibited the kinases Aurora A/B, JAK2, ABL1, and CHEK1. It induced apoptosis in chronic lymphocytic leukemia (CLL) cells and acted synergistically with BTK inhibitors against CLL cells. It inhibited neuroblastoma cell growth and enhanced sensitivity to conventional chemotherapy. Dubermatinib was also active in a drug-resistant acute myeloid leukemia model and reduced metastasis and therapy resistance in pancreatic cancer models.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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