Autophinib, Autophagy inhibitor (TBI3476)
$144.00 – $396.00
Autophagy inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3476-5MG | Yes | 5 MG | $144.00 | |||
TBI3476-25MG | Yes | 25 MG | $396.00 |
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Description
Product Details
Formal Name: 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-4-pyrimidinamine
Molecular Formula: C14H11ClN6O3
Formula Weight: 346.70
CAS Number: 1644443-47-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Autophagy inhibitor
Functions
Autophinib inhibits autophagy induced by starvation or rapamycin by inhibiting the lipid kinase VPS34 (IC50=19 nM). Increased autophagy and apoptosis were rescued by autophinib in Per1-overexpressing oral squamous cell carcinoma cells. Autophinib has quickly become an important biochemical tool for inhibition of autophagy in a variety of cellular contexts.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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