Remodelin, Acetyl-transferase NAT10 inhibitor (TBI5085)
$117.00 – $504.00
Acetyl-transferase NAT10 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5085-5MG | Yes | 5 MG | $117.00 | |||
TBI5085-25MG | Yes | 25 MG | $504.00 |
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Description
Product Details
Formal Name: 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile
Molecular Formula: C15H14N4S
Formula Weight: 282.36
CAS Number: 949912-58-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 40 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Acetyl-transferase NAT10 inhibitor
Functions
Potent and selective inhibitor of N-acetyltransferase 10 (NAT10) which is capable of acetylating microtubules and histones. Improves nuclear architecture, chromatin organization and fitness of both human lamin A/C-depleted cells and Hutchinson-Gilford progeria syndrome patient cells, normalizing progeric and aging cells. Enhances health span in a mouse model of human accelerated aging syndrome. Significantly reduces many of the defects associated with accumulation of the lamin A precursor, prelamin A. Inhibits NAT10-promoted metastasis which may be mediated by endothelial-to-mesenchymal transition in hepatocellular carcinoma.
Application Procedures
First dissolved in DMSO (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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