Pomalidomide, Cereblon ubiquitination inhibitor (TBI2768)
$90.00 – $270.00
Cereblon ubiquitination inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2768-20MG | Yes | 20 MG | $90.00 | |||
TBI2768-100MG | Yes | 100 MG | $270.00 |
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Description
Product Details
Formal Name: 1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline
Alternate Names: 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide
Molecular Formula: C13H11N3O4
Formula Weight: 273.24
CAS Number: 19171-19-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Cereblon ubiquitination inhibitor
Functions
Thalidomide analog. Inhibits cereblon (CRBN) an E3 ubiquitin ligase, IC50 ~3 M for CRBN-DDB1 complex. Displays antiangiogenic and immunomodulatory activity in vivo potently inhibiting the production of TNFα and IL-2. Promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome. Conjugation with other ligands is a strategy to target proteins for in vivo proteasomal degradation via PROTACS.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 20 MG, 100 MG |
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