gamma-L-Glutamyl-p-nitroanilide HCl, L-glutamine uptake inhibitor and gamma-glutamyl transpeptidase substrate (TBI4568)
$36.00 – $54.00
L-glutamine uptake inhibitor and gamma-glutamyl transpeptidase substrate
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4568-100MG | Yes | 100 MG | $36.00 | |||
TBI4568-250MG | Yes | 250 MG | $54.00 |
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Description
Product Details
Alternate Names: GPNA
Molecular Formula: C11H13N3O5 · HCl
Formula Weight: 303.70
CAS Number: 67953-08-6
Purity: >98%
Formulation: powder
Solubility: Soluble in Water (up to 5 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
L-glutamine uptake inhibitor and gamma-glutamyl transpeptidase substrate
Functions
L-γ-Glutamyl-p-nitroanilide (GPNA) is a substrate for γ-glutamyl transpeptidase. GPNA is used for the determination of γ-glutamyl transpeptidase hydrolytic activity via spectrophotometric monitoring of p-nitroaniline released by the action of the enzyme on GPNA. GPNA has also been shown to be an inhibitor of glutamine uptake – solute-linked carrier family A1 member 5 (SLC1A5). Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.
Application Procedures
First dissolved in Water (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in distilled water may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 250 MG, 100 MG |
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