Erlotinib HCl, EGFR Kinase inhibitor (TBI2135)
$63.00 – $135.00
EGFR Kinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2135-10MG | Yes | 10 MG | $63.00 | |||
TBI2135-100MG | Yes | 100 MG | $135.00 |
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Description
Product Details
Formal Name: N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride
Molecular Formula: C22H23N3O4 · HCl
Formula Weight: 429.91
CAS Number: 183319-69-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 18 mg/ml with warming).
Storage: -20°C
Stability: ≥ 1 year.
Applications
EGFR Kinase inhibitor
Functions
Potent inhibitor of EGFR tyrosine kinase (IC50 = 2 nM). Potent inhibitor of mutant JAK2-V617F. Weaker inhibitor of ErbB-2 kinase (Ki = 1 μM) ErbB-4 kinase (Ki = 1.5 μM). HDAC inhibitors sensitize for erlotinib activity in EGFR-mutated and wildtype non-small cell lung cancer (NSCLC) cells. A clinically effective agent for NSCLC.
Application Procedures
First dissolved in DMSO (up to 18 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 10 MG, 100 MG |
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