FH-535, Wnt/β-catenin inhibitor (TBI1328)

Description

Product Details

Formal Name: 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide

Molecular Formula: C₁₃H₁₀Cl₂N₂O₄S

Formula Weight: 361.21

CAS Number: 108409-83-2

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

 

Applications

Wnt/β-catenin inhibitor

 

Functions

Suppresses Wnt/β-catenin signaling.  It antagonizes PPARγ and PPARδ ligand-dependent activation which is mediated by inhibition of recruitment of the coactivators β-catenin and GRIP1 but not the corepressors NCoR and SMRT1. Inhibits the migration and growth of breast cancer cell lines as well as colon, lung and liver cell lines. Useful tool for probing the involvement of Wnt signaling pathway.

 

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.

 

Additional information

SIZE (mg)	10 MG, 50 MG

TBI1328_FH-535