AC1903, TRPC5 blocker (TBI3375)
$126.00 – $504.00
TRPC5 blocker
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3375-10MG | Yes | 10 MG | $126.00 | |||
TBI3375-50MG | Yes | 50 MG | $504.00 |
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Description
Product Details
Formal Name: 1-Benzyl-1H-benzoimidazol-2-yl)-furan-2-ylmethyl-amine
Molecular Formula: C19H17N3O
Formula Weight: 303.36
CAS Number: 831234-13-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml) or in ethanol (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
TRPC5 blocker
Functions
A potent and selective TRPC5 blocker. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis. It also provided therapeutic benefit in a rat model of hypertensive proteineuric kidney disease. The use of this selective tool compound provided a mechanistic rationale for targeting TRPC5 channels in progressive chronic kidney diseases and paves the way for the discovery of new therapeutics. Active in vivo.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml) or in ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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