Azoramide, UPR modulator (TBI4629)
$90.00 – $315.00
UPR modulator
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4629-10MG | Yes | 10 MG | $90.00 | |||
TBI4629-50MG | Yes | 50 MG | $315.00 |
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Description
Product Details
Formal Name: N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide
Molecular Formula: C15H17ClN2OS
Formula Weight: 308.83
CAS Number: 932986-18-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
UPR modulator
Functions
Azoramide is a modulator of the unfolded protein response (UPR). It improves endoplasmic reticulum (ER) protein folding and activates ER chaperone capacity to protect cells against ER stress. It displayed potent anti-diabetic activity in two mouse models by improving insulin sensitivity and pancreatic β cell function. Azoramide increased SERCA expression leading to enhanced calcium retention in the ER indicating calcium homeostasis as a possible mechanism for its anti-diabetic acitivty.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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