a-Mangostin, STING agonist (human) (TBI3433)
$81.00 – $270.00
STING agonist (human)
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI3433-10MG | Yes | 10 MG | $81.00 | |||
TBI3433-50MG | Yes | 50 MG | $270.00 |
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Description
Product Details
Formal Name: 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
Alternate Names: Mangostine; Mangostin
Molecular Formula: C24H26O6
Formula Weight: 410.46
CAS Number: 6147-11-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
STING agonist (human)
Functions
α-Mangostin is a xanthone natural product that has historically been used in traditional folk medicine. It is a potent agonist of human STING (Stimulator of Interferon Genes) and also weakly activates mouse STING. Induces IFN- production and repolarizes human monocyte-derived M2 macrophages to M1. Improves insulin secretion and protects INS-1 cells from streptozotocin-induced damage. Suppresses the metastasis of human renal carcinoma cells. Synergizes with kinase inhibitors in suppression of proliferation of SK-MEL-2 malignant melanoma cells.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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