Talabostat mesylate, Pyroptosis inducer; Inflammasome activator (TBI4005)
$108.00 – $423.00
Pyroptosis inducer; Inflammasome activator
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4005-10MG | Yes | 10 MG | $108.00 | |||
TBI4005-50MG | Yes | 50 MG | $423.00 |
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Description
Product Details
Formal Name: ((2R)-1-((2S)-2-Amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic acid methanesulfonate
Alternate Names: Val-boroPro; PT-100
Molecular Formula: C9H19BN2O3·CH3SO3H
Formula Weight: 310.18
CAS Number: 1510080-09-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Pyroptosis inducer; Inflammasome activator
Functions
Talabostat mesylate is a non-selective inhibitor of the S9 family of serine proteases (IC50’s: DPPIV = <4nM, DPP8 = 4nM, DPP9 = 11nM, QPP = 310nM, FAP = 560nM, PEP = 390nM). Toxicity caused by DPP8/9 inhibition observed with non-selective DPPIV inhibitors limits their use as a diabetes treatment. However, Talabostat displays potent antitumor effects dependent on an intact host immune response. It mediates tumor regression by accelerating the expansion of tumor-specific T cells. Additionally, DPP8/9 inhibition by Talabostat activates the proprotein form of Caspase-1 leading to a proinflammatory form of cell death in monocytes and macrophages – pyroptosis. Pyroptosis induction by DPP8/9 inhibition has been shown to be caused by activation of the inflammasome sensor protein Nlrp1b.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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