Tranilast, NFkB inhibitor (TBI2234)

Description

Product Details

Formal Name: N-(3’,4’-Dimethoxycinnamoyl)anthranilic acid

Alternate Names: Rizaben

Molecular Formula: C₁₈H₁₇NO₅

Formula Weight: 327.34

CAS Number: 53902-12-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml).

Storage: RT

Stability: ≥ 1 year.

 

Applications

NFkB inhibitor

 

Functions

Tranilast is an anti-allergy agent (inhibition of mast cell degranulation) that has been shown to have potent immunomodulatory effects (via inhibition of endotoxin induced: PGE2, IC50 = 1-20 µM; TXB2, IC50 = 10-50 µM; TGFβ1, IC50 = 100-200 µM; IL-8, IC50 = 100 µM) . Tranilast also displays anti-angiogenic properties.

 

Application Procedures

First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

 

Additional information

SIZE (mg)	10 MG, 50 MG

TBI2234_Tranilast