ISRIB, Integrated stress response inhibitor (TBI1539)
$108.00 – $432.00
Integrated stress response inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1539-5MG | Yes | 5 MG | $108.00 | |||
TBI1539-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: N.N’-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide
Alternate Names: trans-ISRIB
Molecular Formula: C22H24Cl2N2O4
Formula Weight: 451.34
CAS Number: 1597403-47-8
Purity: >98%
Formulation: powder
Solubility: DMSO (up to 5 mg/ml with warming)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Integrated stress response inhibitor
Functions
Integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM. Enhances spatial and fear-associated learning in mice and enhances cognitive function. Mechanism of action involves activation of eiF2β.3 Suppresses ER stress-induced inflammatory gene expression. Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production. Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.
Application Procedures
First dissolved in DMSO (up to 5 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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