VGX-1027, Immunomodulator; Cytokine release inhibitor (TBI3409)
$81.00 – $288.00
Immunomodulator; Cytokine release inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3409-5MG | Yes | 5 MG | $81.00 | |||
TBI3409-25MG | Yes | 25 MG | $288.00 |
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Description
Product Details
Formal Name: 4,5-Dihydro-3-phenyl-5-isoxazoleacetic acid
Alternate Names: GIT 27
Molecular Formula: C11H11NO3
Formula Weight: 205.2
CAS Number: 6501-72-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Immunomodulator; Cytokine release inhibitor
Functions
Immunomodulator. Inhibits secretion of IL-1β, TNF-α, and IL-10 from murine macrophages stimulated with LPS and spares T cell function. Ameliorates the course of acute and chronic immunoinflammatory conditions such as carrageenan-induced pleurisy, LPS-induced lethality and type II collagen-induced arthritis in mouse models. Prevents spontaneous and accelerated forms of autoimmune diabetes in a NOD mouse model. Moldulates genes involved in LPS-induced Toll-like receptor 4 activation in a mouse Lupus model. Displays protective effects in particulate matter-induced acute lung injury by blocking TLR4 signaling.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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