Verteporfin, YAP inhibitor; Anticancer activity (TBI3487)
$135.00 – $540.00
YAP inhibitor; Anticancer activity
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI3487-5MG | Yes | 5 MG | $135.00 | |||
TBI3487-25MG | Yes | 25 MG | $540.00 |
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Description
Product Details
Formal Name: (4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
Alternate Names: CL 318,952; BPD-MA
Molecular Formula: C41H42N4O8
Formula Weight: 718.80
CAS Number: 129497-78-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 14 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
YAP inhibitor; Anticancer activity
Functions
Photosensitive drug used to ablate unwanted neovasculature in the eye, esophageal mucosa, and elsewhere using light to create damaging free radicals and high-molecular-weight crosslinked oligomers. Independent of light exposure, verteporfin inhibits transcription by YAP/TAZ (via disruption of YAP-TEAD interaction)(IC50 = 2.5 µM), inhibiting autophagy and halting proliferation of cancer and cancer stem cell lines. Inhibits autophagosome formation. Reverses differentiation of Src-overexpressing embryonic stem cells, and blocks SARS-CoV-2 infection in vitro and in vivo.
Application Procedures
First dissolved in DMSO (up to 14 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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