UPF-1069, PARP-2 inhibitor (TBI3779)
$99.00 – $306.00
PARP-2 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3779-5MG | Yes | 5 MG | $99.00 | |||
TBI3779-25MG | Yes | 25 MG | $306.00 |
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Description
Product Details
Formal Name: 5-(2-Oxo-3-phenylethoxy)-1(2H)-isoquinolinone
Molecular Formula: C17H13NO3
Formula Weight: 279.30
CAS Number: 1048371-03-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO up to 40 mg/ml
Storage: -20°C
Stability: ≥ 2 years.
Applications
PARP-2 inhibitor
Functions
PARP inhibitor selective for PARP-2 (IC50=0.3 μM; ~ 27-fold selective against PARP-1). Increases apoptosis in hippocampal slices but protects cortical cells in models of post-ischemic brain damage. Blocks the interaction between PARP-2 and FOXA1, attenuating androgen receptor-mediated gene expression and inhibiting androgen receptor-positive prostate cancer growth.
Application Procedures
First dissolved in DMSO up to 40 mg/ml, then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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