UNC1999, Methyltransferase inhibitor (TBI4542)
$106.00 – $360.00
Methyltransferase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4542-5MG | Yes | 5 MG | $106.00 | |||
TBI4542-25MG | Yes | 25 MG | $360.00 |
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Description
Product Details
Formal Name: N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide
Molecular Formula: C33H43N7O2
Formula Weight: 569.74
CAS Number: 1431612-23-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 10 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Methyltransferase inhibitor
Functions
UNC1999 is an orally active, highly selective inhibitor of both wild-type and mutant EZH1 and EZH2 lysine methyltransferases (IC50’s = 45 nM and 2 nM respectively). Inhibition of EZH2 with UNC1999 enhanced the efficacy of gefitinib in suppressing the proliferation of colon cancer cells. It suppresses global H3K27 trimethylation/demethylation and inhibits the growth of mixed lineage leukemia (MLL)-rearranged leukemia cells.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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