UK-5099, Mitochondrial pyruvate carrier inhibitor; cell impermeable (TBI1447)
$126.00 – $504.00
Mitochondrial pyruvate carrier inhibitor; cell impermeable
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI1447-5MG | Yes | 5 MG | $126.00 | |||
TBI1447-25MG | Yes | 25 MG | $504.00 |
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Description
Product Details
Formal Name: 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
Molecular Formula: C18H12N2O2
Formula Weight: 288.30
CAS Number: 56396-35-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 8 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Mitochondrial pyruvate carrier inhibitor; cell impermeable
Functions
Potent inhibitor of the mitochondrial pyruvate carrier (MPC). Rapidly increases glucose uptake in human monocytes. Attenuates mitochondrial oxidative phosphorylation and increases glycolysis creating greater stem-like properties in LnCap prostate cancer cells. Blocks the neuroprotective action of L-lactate or pyruvate during glutamate-induced excitotoxicity. Inhibits pyruvate transport across the plasma membrane of trypanosomes (Ki=49 μM).
Application Procedures
First dissolved in DMSO (up to 30 mg/ml) or in Ethanol (up to 8 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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