UCPH-101, EAAT1 inhibitor (TBI4880)

Description

Product Details

Formal Name: 2-Amino-4-(4-methoxyphenyl)-7-naphthalen-1-yl-5-oxo-4,6,7,8-tetrahydrochromene-3-carbonitrile

Molecular Formula: C₂₇H₂₂N₂O₃

Formula Weight: 422.48

CAS Number: 1118460-77-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 10 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

 

Applications

EAAT1 inhibitor

 

Functions

UCPH-101 is a potent (IC50 = 660 nM) and selective inhibitor of the excitatory amino acid transporter 1 (EAAT1). It induced cell death in glioblastoma cells via intracellular glutamate accumulation. UCPH-101 also significantly increased survival in glioma-bearing mice.

 

Application Procedures

First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.

Additional information

SIZE (mg)	25 MG, 5 MG

TBI4880_Data_Sheet