SR-8278, RevErb a antagonist (TBI1506)
$140.00 – $562.00
RevErb a antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1506-5MG | Yes | 5 MG | $140.00 | |||
TBI1506-25MG | Yes | 25 MG | $562.00 |
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Description
Product Details
Formal Name: 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester
Molecular Formula: C18H19NO3S2
Formula Weight: 361.49
CAS Number: 1254944-66-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 35 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
RevErb a antagonist
Functions
Antagonist of the nuclear heme receptor, REV-ERB. Blocks the ability of the REV-ERBα agonist, GSK4112, to enhance REV-ERB-dependent repression in a cotransfection assay. Decreases glucagon secretion and intracellular calcium signals in alphaTC1-9 cells and mouse primary alpha cells. Enhances the expression of bone morphogenetic protein genes in rat uterus endometrium stromal cells. Shortens the period of circadian oscillations in mature granulosa cells stimulated with or without LH.
Application Procedures
First dissolved in DMSO (up to 60 mg/ml) or in Ethanol (up to 35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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