SR-1001, RORag agonist (TBI1290)
$144.00 – $576.00
RORag agonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1290-5MG | Yes | 5 MG | $144.00 | |||
TBI1290-25MG | Yes | 25 MG | $576.00 |
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Description
Product Details
Formal Name: N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulphamoyl)-4-methylthiazol-2-yl)acetamide
Molecular Formula: C15H13F6N6O4S2
Formula Weight: 477.39
CAS Number: 1335106-03-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
RORag agonist
Functions
A high affinity synthetic ligand for both RORα and RORγt acting as an inverse agonist. It binds specifically to the ligand-binding domain, inducing a conformational change which leads to diminished affinity for co-activators and increased affinity for co-repressors resulting in suppression of transcriptional activity. It inhibits the development of murine TH17 cells and suppresses the expression of cytokines. Suppresses insulitis and prevents hyperglycemia in a type 1 diabetes mouse model. Protects against pathologic neovascularization in various mouse models of retinopathy. Active in vivo
Application Procedures
First dissolved in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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