Sphingosine, PKC inhibitor (TBI2287)
$122.00 – $378.00
PKC inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2287-20MG | Yes | 20 MG | $122.00 | |||
TBI2287-100MG | Yes | 100 MG | $378.00 |
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Description
Product Details
Formal Name: (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol
Alternate Names: D(+)-erythro-1,3-Dihydroxy-2-amino-4-trans-octadecene
Molecular Formula: C18H37NO2
Formula Weight: 299.50
CAS Number: 123-78-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml with warming) or in Ethanol (up to 25 mg/ml with warming).
Storage: -20°C
Stability: ≥ 1 year.
Applications
PKC inhibitor
Functions
Endogenous sphingolipid found in cells esterified as phosphatidylcholine (sphingomyelin) and released by the action of sphingomyelinases. Potent and selective inhibitor of protein kinase C (IC50=1-3 µM). Inhibition is competitive with DAG, phorbol esters and Ca2+. May be phosphorylated by sphingosine kinases producing sphingosine-1-phosphate, a bioactive lipid producing a plethora of biological effects.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml with warming) or in Ethanol (up to 25 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 20 MG, 100 MG |
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