SP2509, LSD1 Inhibitor (TBI4019)
$126.00 – $486.00
LSD1 Inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4019-5MG | Yes | 5 MG | $126.00 | |||
TBI4019-25MG | Yes | 25 MG | $486.00 |
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Description
Product Details
Formal Name: (E)-N’-(1-(5-Chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide
Molecular Formula: C19H20ClN3O5S
Formula Weight: 437.90
CAS Number: 1423715-09-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
LSD1 Inhibitor
Functions
SP2509 is a potent (IC50 = 13 nM), reversible, non-competitive inhibitor of histone demethylase LSD1 (KDM1A), selective over the closely related flavin enzymes MAO A & B, lactate dehydrogenase, several CYPs, or hERG1. It inhibits growth and induces differentiation of cancer stem cells, e.g. AML progenitor cells, and promotes autophagy in neuroblastoma cells. It also causes cancer cell death independent if LSD1, possibly through downregulation of Bcl-2 and Mcl-1. Also inhibits HSV-1 infection by blocking viral DNA replication and gene expression.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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