SirtAct (CAY-10591), SIRT1 activator (TBI2595)
$144.00 – $576.00
SIRT1 activator
| SKU | Stock | SIZE (mg) | Price | Quantity | ||
|---|---|---|---|---|---|---|
| TBI2595-5MG | Yes | 5 MG | $144.00 | |||
| TBI2595-25MG | Yes | 25 MG | $576.00 |
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Description
Product Details
Formal Name: 2-Amino-N-cyclopentyl-1-(3-methoxypropyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide
Alternate Names: CAY10591
Molecular Formula: C20H25N5O2
Formula Weight: 367.46
CAS Number: 839699-72-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
SIRT1 activator
Functions
Sirt1 activator (233% at 10 μM) Suppresses TNFα release from THP-1 cells and stimulates adipogenesis in 3T3L1 cells. SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice. Inhibits NFκB activation and reduces inflammatory cytokine production in lamina propria mononuclear cells from IBD patients. Prevents and cures experimental colitis in a mouse model.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Additional information
| SIZE (mg) | 25 MG, 5 MG |
|---|
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