Siramesine, Selective sigma-2 agonist (TBI4202)
$126.00 – $450.00
Selective sigma-2 agonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4202-5MG | Yes | 5 MG | $126.00 | |||
TBI4202-25MG | Yes | 25 MG | $450.00 |
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Description
Product Details
Formal Name: 1’-[4-[1-(4-Fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4’-piperidine;
Alternate Names: Lu 28-179
Molecular Formula: C30H31FN2O
Formula Weight: 454.59
CAS Number: 147817-50-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Selective sigma-2 agonist
Functions
Siramesine (Lu 28-179) is a σ2 selective agonist (IC50’s: σ1 = 17nM, σ2 = 0.2nM). It produced non-sedating potent and long-last anxiolytic effects in rodents. Siramesine induced caspase-independent programmed cell death in various cancer cell lines via increased levels of ROS and lysosomal leakage. Mitochondrial destabilization via loss of membrane potential and increased ROS has also been offered as a mechanism of action for the triggering of cell death by Siramesine.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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