SBI-0206965, ULK1 inhibitor (TBI1623)
$117.00 – $468.00
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI1623-5MG | Yes | 5 MG | $117.00 | |||
TBI1623-25MG | Yes | 25 MG | $468.00 |
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Description
Product Details
Formal Name: 2-((5-Bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide
Molecular Formula: C21H21BrN4O5
Formula Weight: 489.32
CAS Number: 1884220-36-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
ULK1 inhibitor
Functions
A potent and selective inhibitor of the autophagy kinase ULK-1, IC50=108 and 711 nM for ULK1 and 2 respectively. Suppresses autophagy induced by mTOR inhibitors and thus synergizes with mTOR inhibitors to induce apoptosis and cell death in tumor cells.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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