Santacruzamate A, Ultrapotent HDAC2 inhibitor (TBI3613)
$72.00 – $288.00
Ultrapotent HDAC2 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3613-5MG | Yes | 5 MG | $72.00 | |||
TBI3613-25MG | Yes | 25 MG | $288.00 |
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Description
Product Details
Formal Name: N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester
Molecular Formula: C15H22N2O3
Formula Weight: 278.35
CAS Number: 1477949-42-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Ultrapotent HDAC2 inhibitor
Functions
A highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca (IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively). Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors. Potential therapeutic agent for breast cancer. Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance. Ameliorates Alzheimer’s disease-like pathology in mouse models.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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