SB-705498, TRPV1 antagonist (TBI3985)

Description

Product Details

Formal Name: 1-(2-Bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)pyridine-2-yl]pyrrolidine-3-yl]urea

Molecular Formula: C₁₇H₁₆BrF₃N₄O

Formula Weight: 429.20

CAS Number: 501951-42-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

 

Applications

TRPV1 antagonist

 

Functions

SB-705498 is a potent and selective antagonist of the TRPV1 receptor (IC50’s for receptor induction method: Capsaicin = 3 nM; Acid (pH5.3) = pIC50 7.1, and Heat = 6 nM) with activity in human, rat, and guinea pig receptors. SB-705498s activity is voltage dependent and shows >100 fold selectivity over the closely related TRPM8 receptor.

 

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Additional information

SIZE (mg)	25 MG, 5 MG

Datasheet:

TBI3985_SB-705498

MSDS:

TBI3985_SB-705498_MSDS_2024