SB-203580, p38 MAP kinase inhibitor (TBI2173)
$108.00 – $432.00
p38 MAP kinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2173-5MG | Yes | 5 MG | $108.00 | |||
TBI2173-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)imidazoledihydro-imidazole-1-carbonyl]-piperazin-2-one
Molecular Formula: C21H16N3OSF
Formula Weight: 377.44
CAS Number: 152121-47-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 10 mg/ml with warming).
Storage: -20°C
Stability: ≥ 2 years.
Applications
p38 MAP kinase inhibitor
Functions
A potent and selective inhibitor of p38 MAP kinase, IC50=50 and 500 nM for p38 and p38β2 respectively. No other kinases (in a panel of 30) were significantly inhibited including p38γ and δ at 10 μM. A potent inhibitor of inflammatory cytokine production (IC50=15-25 mg/kg in mice and rats) in animal models of arthritis, bone resorption, endotoxin shock and immune function.
Application Procedures
First dissolved in DMSO (up to 100 mg/ml) or in Ethanol (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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