RS-1, RAD51 activator; CRISPR enhancer (TBI4099)
$81.00 – $279.00
RAD51 activator; CRISPR enhancer
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4099-10MG | Yes | 10 MG | $81.00 | |||
TBI4099-50MG | Yes | 50 MG | $279.00 |
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Description
Product Details
Formal Name: 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide
Molecular Formula: C20H16BrN2O3S
Formula Weight: 524.23
CAS Number: 312756-74-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml)
Storage: RT
Stability: ≥ 1 year.
Applications
RAD51 activator; CRISPR enhancer
Functions
RAD51 is a strand exchange protein that is critical for the central steps in homologous recombination (HR) of DNA during double strand break repair. Because HR usually occurs without mutations, it is critically important for maintaining genomic stability. RS-1 is a small molecule that enhances the HR activity of RAD51 by promoting the formation of active presynaptic filaments during repair. At low micromolar levels, it was able to increase cellular resistance of neonatal human dermal fibroblasts to the chemotherapeutic agent cisplatin. HR stimulation in various cell types could lead to temporary protection from DNA damaging agents. RS-1 has been used to exploit the RAD51 overexpression in cancerous cells by inducing lethality via genotoxic RAD51 protein complexes. RS-1 has also been found to a potent enhancer of CRISPR- and TALEN- based gene editing.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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