R428, Potent and selective AXL inhibitor (TBI4676)
$135.00 – $495.00
Potent and selective AXL inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4676-5MG | Yes | 5 MG | $135.00 | |||
TBI4676-25MG | Yes | 25 MG | $495.00 |
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Description
Product Details
Formal Name: 1-(3,4-Diazatricyclo[9.4.0.02,7]pentadeca-1(15),2,4,6,11,13-hexaen-5-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine
Alternate Names: Bemcentinib; BGB324
Molecular Formula: C30H34N8
Formula Weight: 506.64
CAS Number: 1037624-75-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Potent and selective AXL inhibitor
Functions
R428 (1037624-75-1) is a potent and selective inhibitor of AXL kinase (IC50 = 1.4nM). R428 has been shown to overcome chemotherapy resistance to various agents in multiple cancer models. AXL has been shown to suppress myeloid cell activation and function – combined AXL inhibition with R428 and PD-1 blockade showed potent synergistic antitumor effects.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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