PTC-209, BMI-1 inhibitor (TBI4022)
$117.00 – $432.00
BMI-1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4022-5MG | Yes | 5 MG | $117.00 | |||
TBI4022-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazol[1,2-a]pyrimidin-3-yl)-2-thiazolamine
Molecular Formula: C17H13Br2N5OS
Formula Weight: 495.20
CAS Number: 315704-66-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
BMI-1 inhibitor
Functions
Inhibitor of BMI-1 (IC50 = 500 nM), part of the polycomb repressive complex 1 (PCR1). It inhibited endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells resulting in reduced tumor volume as well as reduced cancer initiating cell (CIC) number. PTC-209 displayed potent in vivo antitumor effects in several cancer models including breast, head and neck, glioblastoma, prostate, colon, and rhabdomyosarcoma. It also promoted chemically-induced direct cardiac reprogramming of cardiac fibroblasts into cardiac myocytes.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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