Piperlongumine, Glutathione sponge; Increases ROS (TBI2377)
$54.00 – $216.00
Glutathione sponge; Increases ROS
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2377-20MG | Yes | 20 MG | $54.00 | |||
TBI2377-100MG | Yes | 100 MG | $216.00 |
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Description
Product Details
Formal Name: (E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one
Molecular Formula: C17H19NO5
Formula Weight: 317.34
CAS Number: 20069-09-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
Glutathione sponge; Increases ROS
Functions
Elevates cellular levels of reactive oxygen species selectively in cancer cell lines. Irreversible glutathionylation leading to depletion of cellular glutathione is associated with its cellular toxicity. Piperlongamine does not appear to have any effect on normal cells. Displays anti-tumor effects in a mouse xenograft tumor model as well as in spontaneously formed malignant breast tumors in mice. Elevation of ROS levels may be due to inhibition of ubiquitin-proteasome system at a pre-proteasomal step.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in water may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 20 MG, 100 MG |
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