PI-103, PI3K, mTOR and DNA-PK inhibitor (TBI5406)
$108.00 – $432.00
PI3K, mTOR and DNA-PK inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5406-5MG | Yes | 5 MG | $108.00 | |||
TBI5406-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: 3-[4-(4-morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl]-phenol
Molecular Formula: C19H16N4O3
Formula Weight: 348.40
CAS Number: 371935-74-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (40 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
PI3K, mTOR and DNA-PK inhibitor
Functions
A potent inhibitor of PI-3 kinase, mTOR and DNA-PK, IC50 = 8, 88, 150, 48, 20, 83 and 2 nM for p110α, p110β, p110ɣ, p110δ, mTORC1, mTORC2 and DNA-PK respectively. Synergizes with arsenic disulfide to eradicate AML stem cells by induction of differentiation. Inhibits the growth of gefitinib-resistant non-small cell lung cancer cell lines. Induces autophagy in drug-resistant glioma. Protects against a-synuclein-induced toxicity in human neurons by induction of macroautophagy.
Application Procedures
First dissolved in DMSO (40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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