PFI-3, Bromodomain inhibitor (TBI4034)
$106.00 – $387.00
Bromodomain inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4034-5MG | Yes | 5 MG | $106.00 | |||
TBI4034-25MG | Yes | 25 MG | $387.00 |
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Description
Product Details
Formal Name: (2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(pyridine-2-yl)-2,5-diazabicyclo{2.2.1]heptan-2-yl]prop-2-en-1-one
Molecular Formula: C19H19N3O2
Formula Weight: 321.40
CAS Number: 1819363-80-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Bromodomain inhibitor
Functions
PFI-3 is a selective inhibitor of family VIII bromodomains PB1(5), SMARCA2, and SMARCA4. It showed complete selectivity over all non-family VIII bromodomains. PFI-3 blocked adipogenesis in C3H10T1/2 mesenchymal cells at 20µM.Treatment of embryonic stem cells with PFI-3 led to deprivation of stemness and deregulated lineage specificity. Differentiation of trophoblast stem cells in the presence of PFI-3 was enhanced. Cell permeable.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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