PF-06840003, IDO1 inhibitor (TBI4498)
$108.00 – $378.00
IDO1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4498-5MG | Yes | 5 MG | $108.00 | |||
TBI4498-25MG | Yes | 25 MG | $378.00 |
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Description
Product Details
Formal Name: 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione
Alternate Names: EOS200271
Molecular Formula: C12H9FN2O2
Formula Weight: 232.21
CAS Number: 198474-05-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
IDO1 inhibitor
Functions
PF-06840003 (198474-05-4) is a potent (IC50 = 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1). In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy. PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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