NSC-59984, p53 activator (TBI3148)
$108.00 – $360.00
p53 activator
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI3148-5MG | Yes | 5 MG | $108.00 | |||
TBI3148-25MG | Yes | 25 MG | $360.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: (E)-1-(4-Methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one
Molecular Formula: C12H15N3O4
Formula Weight: 265.27
CAS Number: 803647-40-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
p53 activator
Functions
p53 activator. Restores wild-type p53 signaling and depletes mutant p53 gain of function. Induces mutant p53 protein degradation via MDM2 and ubiquitin-proteasome pathway. Induces p73-dependent cell death in cancer cells without toxicity toward normal cells. Inhibition of p53-MDM2 interaction remains a viable strategy for cancer therapeutic development.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “NSC-59984, p53 activator (TBI3148)”
You must be logged in to post a review.
Reviews
There are no reviews yet.