NG52, Phosphoglycerate kinase 1 inhibitor (TBI4681)
$144.00 – $531.00
Phosphoglycerate kinase 1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4681-5MG | Yes | 5 MG | $144.00 | |||
TBI4681-25MG | Yes | 25 MG | $531.00 |
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Description
Product Details
Formal Name: 2-[[6-(3-Chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol; 2-(2-Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine
Molecular Formula: C16H19ClN6O
Formula Weight: 346.82
CAS Number: 212779-48-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Phosphoglycerate kinase 1 inhibitor
Functions
Inhibitor of Cdc2-cyclin B (IC50 = 340 nM) as well as Cdc28p (IC50 = 7 µM) and Pho85p (IC50 = 2 µM). It inhibited phosphoglycerate kinase 1 (IC50 = 2.5 µM) and inhibited the proliferation of glioma U87 and U251 cell lines via reversal of the Warburg effect. NG52 inhibited the proliferation, increased apoptosis, and reduced the migration and invasive ability of OVCAR3 and ES-2 ovarian cancer cell lines via suppression of glycolytic capability.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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