Necrosulfonamide, Pyroptosis / necroptosis inhibitor; MLKL pseudokinase inhibitor (TBI4860)
$67.00 – $288.00
Pyroptosis / necroptosis inhibitor; MLKL pseudokinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4860-5MG | Yes | 5 MG | $67.00 | |||
TBI4860-25MG | Yes | 25 MG | $288.00 |
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Description
Product Details
Formal Name: (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide
Molecular Formula: C18H15N5O6S2
Formula Weight: 461.47
CAS Number: 1360614-48-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 10 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Pyroptosis / necroptosis inhibitor; MLKL pseudokinase inhibitor
Functions
Specifically blocks necroptosis downstream of RIP3 activation by preventing MLKL-RIP3 interaction. Displays neuroprotective effects after ischemic brain injury. Prevents cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells. Binds to gasdermin D inhibiting pyroptosis and associated inflammatory cell death and sepsis. Rescues cells from TLR3 ligand-induced death.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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